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In a preferred embodiment, the parent Tet repressors from which the chimeric repressors of the present invention are constructed are TetR of classes B and D (see Schnappinger et al, (1998) EMBO J!

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Cells were incubated with DOXY or MINO in final concentrations of 25, misoprostol costo 10 and 25 µg/ml or COL-3 in final concentrations of 075, 1 and 5 µg/ml until 24 h.